Are there nonstop flights from Sukkur (SKZ) to Karachi (KHI)?

Yes. Pakistan International Airlines fly this route. Flight time is about 55m.

Sukkur → Karachi

Begum Nusrat Bhutto International Airport Sukkur (SKZ) to Jinnah International Airport (KHI)・353 km

Nonstop flights available (1 airline). Flight time about 55m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.