Are there nonstop flights from Karachi (KHI) to Sukkur (SKZ)?

Yes. Pakistan International Airlines fly this route. Flight time is about 55m.

Karachi → Sukkur

Jinnah International Airport (KHI) to Begum Nusrat Bhutto International Airport Sukkur (SKZ)・353 km

Nonstop flights available (1 airline). Flight time about 55m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.