Are there nonstop flights from Islamabad (ISB) to Karachi (KHI)?

Yes. Pakistan International Airlines, airblue, AirSial, Fly Jinnah, Serene Air, South Air fly this route. Flight time is about 1h 48m.

What is the fastest connection from Islamabad (ISB) to Karachi (KHI)?

via Sukkur ≈ 2h 18m, via Multan ≈ 2h 19m, via Bahawalpur ≈ 2h 21m (estimated flying time, excluding layovers).

Islamabad International Airport (ISB) to Jinnah International Airport (KHI)・1,107 km

Nonstop flights available (6 airlines). Flight time about 1h 48m. Nonstop return flights also operate.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.