Are there nonstop flights from Seattle (SEA) to Guadalajara (GDL)?

Yes. Volaris, Aeroméxico fly this route. Flight time is about 4h 33m.

What is the fastest connection from Seattle (SEA) to Guadalajara (GDL)?

via Phoenix ≈ 5h 4m, via Las Vegas ≈ 5h 5m, via Salt Lake City ≈ 5h 7m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Seattle–Tacoma International Airport (SEA) to Guadalajara International Airport (GDL)・3,448 km

Nonstop flights available (2 airlines). Flight time about 4h 33m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via IAH)JAL 23,000 miles+ (via LAX)Economy, one way, estimate. Tap a connection for miles by cabin.

33 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.