Are there nonstop flights from Portland (PDX) to Guadalajara (GDL)?

Yes. Volaris fly this route. Flight time is about 4h 23m.

What is the fastest connection from Portland (PDX) to Guadalajara (GDL)?

via Phoenix ≈ 4h 53m, via Las Vegas ≈ 4h 54m, via Reno ≈ 4h 57m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Portland International Airport (PDX) to Guadalajara International Airport (GDL)・3,297 km

Nonstop flights available (1 airline). Flight time about 4h 23m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via IAH)JAL 23,000 miles+ (via LAX)Economy, one way, estimate. Tap a connection for miles by cabin.

29 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.