Are there nonstop flights from Knoxville/Maryville (TYS) to Sacramento (SMF)?

No. The fastest connection is via Nashville, about 4h 54m of total flying time.

What is the fastest connection from Knoxville/Maryville (TYS) to Sacramento (SMF)?

via Nashville ≈ 4h 54m, via Denver ≈ 4h 55m, via Las Vegas ≈ 5h 2m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to Sacramento International Airport (SMF)・3,320 km

No nonstop flights. The fastest connection is via Nashville (BNA), about 4h 54m of flying time (layover not included).

With milesANA 15,000 miles+ (via DEN)JAL 23,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

19 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.