Are there nonstop flights from Knoxville/Maryville (TYS) to Houston (IAH)?

Yes. United Express fly this route. Flight time is about 1h 58m.

What is the fastest connection from Knoxville/Maryville (TYS) to Houston (IAH)?

via Nashville ≈ 2h 32m, via Memphis ≈ 2h 32m, via Atlanta ≈ 2h 35m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to George Bush Intercontinental Airport (IAH)・1,241 km

Nonstop flights available (1 airline). Flight time about 1h 58m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via DFW)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

20 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.