Are there nonstop flights from Knoxville/Maryville (TYS) to Panama City (PTY)?

No. The fastest connection is via Tampa, about 4h 32m of total flying time.

What is the fastest connection from Knoxville/Maryville (TYS) to Panama City (PTY)?

via Tampa ≈ 4h 32m, via Atlanta ≈ 4h 33m, via Miami ≈ 4h 33m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 30,000 ANA miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to Tocumen International Airport (PTY)・3,010 km

No nonstop flights. The fastest connection is via Tampa (TPA), about 4h 32m of flying time (layover not included).

With milesJAL 15,000 miles+ (via MIA)ANA 30,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.