Are there nonstop flights from Knoxville/Maryville (TYS) to Minneapolis (MSP)?

Yes. Delta Connection fly this route. Flight time is about 2h.

What is the fastest connection from Knoxville/Maryville (TYS) to Minneapolis (MSP)?

via Chicago ≈ 2h 32m, via Chicago ≈ 2h 32m, via South Bend ≈ 2h 35m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field (MSP)・1,274 km

Nonstop flights available (1 airline). Flight time about 2h. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via ORD)JAL 15,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

24 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.