Are there nonstop flights from Knoxville/Maryville (TYS) to New York (LGA)?

Yes. Delta Connection fly this route. Flight time is about 1h 43m.

What is the fastest connection from Knoxville/Maryville (TYS) to New York (LGA)?

via Washington ≈ 2h 14m, via Washington ≈ 2h 14m, via Charlotte ≈ 2h 22m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to LaGuardia Airport (LGA)・1,041 km

Nonstop flights available (1 airline). Flight time about 1h 43m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via CLT)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

15 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.