Are there nonstop flights from Knoxville/Maryville (TYS) to Seoul (ICN)?

No. The fastest connection is via Chicago, about 14h 17m of total flying time.

What is the fastest connection from Knoxville/Maryville (TYS) to Seoul (ICN)?

via Chicago ≈ 14h 17m, via Minneapolis ≈ 14h 18m, via Detroit ≈ 14h 22m (estimated flying time, excluding layovers).

from 45,000 JAL miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to Incheon International Airport (ICN)・11,284 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 14h 17m of flying time (layover not included).

With milesJAL 45,000 miles+ (via DFW)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.