Are there nonstop flights from Knoxville/Maryville (TYS) to Rome (FCO)?

No. The fastest connection is via Boston, about 10h 18m of total flying time.

What is the fastest connection from Knoxville/Maryville (TYS) to Rome (FCO)?

via Boston ≈ 10h 18m, via Newark ≈ 10h 18m, via Washington ≈ 10h 18m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to Rome–Fiumicino Leonardo da Vinci International Airport (FCO)・7,904 km

No nonstop flights. The fastest connection is via Boston (BOS), about 10h 18m of flying time (layover not included).

With milesANA 27,500 miles+ (via ORD)JAL 37,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.