Are there nonstop flights from Knoxville/Maryville (TYS) to Boston (BOS)?

Yes. Allegiant Air fly this route. Flight time is about 2h 4m.

What is the fastest connection from Knoxville/Maryville (TYS) to Boston (BOS)?

via New York ≈ 2h 34m, via Newark ≈ 2h 35m, via Washington ≈ 2h 35m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

McGhee Tyson Airport (TYS) to Boston Logan International Airport (BOS)・1,334 km

Nonstop flights available (1 airline). Flight time about 2h 4m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via CLT)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

20 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.