Are there nonstop flights from Santo Domingo (SDQ) to Holguin (HOG)?

Yes. SKYhigh Dominicana fly this route. Flight time is about 1h 23m.

Santo Domingo → Holguin

Las Américas International Airport (SDQ) to Frank Pais International Airport (HOG)・744 km

Nonstop flights available (1 airline). Flight time about 1h 23m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.