Are there nonstop flights from Holguin (HOG) to Santo Domingo (SDQ)?

Yes. SKYhigh Dominicana fly this route. Flight time is about 1h 23m.

Holguin → Santo Domingo

Frank Pais International Airport (HOG) to Las Américas International Airport (SDQ)・744 km

Nonstop flights available (1 airline). Flight time about 1h 23m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.