Are there nonstop flights from Louisville (SDF) to Santiago (SCL)?

No. The fastest connection is via Atlanta, about 10h 33m of total flying time.

What is the fastest connection from Louisville (SDF) to Santiago (SCL)?

via Atlanta ≈ 10h 33m, via Orlando ≈ 10h 34m, via Miami ≈ 10h 34m (estimated flying time, excluding layovers).

from 37,000 JAL miles (economy, one way, based on the published award charts).

Louisville Muhammad Ali International Airport (SDF) to Comodoro Arturo Merino Benítez International Airport (SCL)・8,106 km

No nonstop flights. The fastest connection is via Atlanta (ATL), about 10h 33m of flying time (layover not included).

With milesJAL 37,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.