Are there nonstop flights from Rochester (ROC) to Des Moines (DSM)?

No. The fastest connection is via Chicago, about 2h 34m of total flying time.

What is the fastest connection from Rochester (ROC) to Des Moines (DSM)?

via Chicago ≈ 2h 34m, via Detroit ≈ 2h 34m, via Chicago ≈ 2h 34m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Frederick Douglass Greater Rochester International Airport (ROC) to Des Moines International Airport (DSM)・1,324 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 2h 34m of flying time (layover not included).

With milesANA 15,000 miles+ (via ORD)JAL 15,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.