Are there nonstop flights from Miami (MIA) to Des Moines (DSM)?

Yes. American Eagle (airline brand) fly this route. Flight time is about 3h 1m.

What is the fastest connection from Miami (MIA) to Des Moines (DSM)?

via Orlando ≈ 3h 32m, via Nashville ≈ 3h 32m, via Atlanta ≈ 3h 32m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Miami International Airport (MIA) to Des Moines International Airport (DSM)・2,137 km

Nonstop flights available (1 airline). Flight time about 3h 1m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via CLT)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

21 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.