Are there nonstop flights from Portland (PWM) to Columbus (CMH)?

Yes. Breeze Airways fly this route. Flight time is about 1h 49m.

What is the fastest connection from Portland (PWM) to Columbus (CMH)?

via Newark ≈ 2h 24m, via New York ≈ 2h 25m, via New York ≈ 2h 26m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Portland International Jetport (PWM) to John Glenn Columbus International Airport (CMH)・1,117 km

Nonstop flights available (1 airline). Flight time about 1h 49m. Nonstop return flights also operate.

With milesJAL 12,000 miles+ (via PHL)ANA 15,000 miles+ (via IAD)Economy, one way, estimate. Tap a connection for miles by cabin.

16 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.