Are there nonstop flights from Palm Springs (PSP) to Des Moines (DSM)?

Yes. Allegiant Air fly this route. Flight time is about 3h 4m.

What is the fastest connection from Palm Springs (PSP) to Des Moines (DSM)?

via Denver ≈ 3h 35m, via Las Vegas ≈ 3h 38m, via Phoenix ≈ 3h 40m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Palm Springs International Airport (PSP) to Des Moines International Airport (DSM)・2,177 km

Nonstop flights available (1 airline). Flight time about 3h 4m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via DEN)JAL 15,000 miles+ (via PHX)Economy, one way, estimate. Tap a connection for miles by cabin.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.