Are there nonstop flights from Chicago (ORD) to Columbia (CAE)?

Yes. American Eagle (airline brand), United Express fly this route. Flight time is about 1h 46m.

What is the fastest connection from Chicago (ORD) to Columbia (CAE)?

via Charlotte ≈ 2h 18m, via Atlanta ≈ 2h 31m, via Washington ≈ 2h 53m (estimated flying time, excluding layovers).

Chicago O'Hare International Airport (ORD) to Columbia Metropolitan Airport (CAE)・1,073 km

Nonstop flights available (2 airlines). Flight time about 1h 46m. Nonstop return flights also operate.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.