Are there nonstop flights from Manchester (MHT) to Buffalo (BUF)?

No. The fastest connection is via Philadelphia, about 2h 5m of total flying time.

What is the fastest connection from Manchester (MHT) to Buffalo (BUF)?

via Philadelphia ≈ 2h 5m, via Baltimore ≈ 2h 15m, via Washington ≈ 2h 19m (estimated flying time, excluding layovers).

Manchester-Boston Regional Airport (MHT) to Buffalo Niagara International Airport (BUF)・594 km

No nonstop flights. The fastest connection is via Philadelphia (PHL), about 2h 5m of flying time (layover not included).

None.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.