Are there nonstop flights from Manchester (MHT) to Chicago (ORD)?

Yes. American Eagle (airline brand) fly this route. Flight time is about 2h 6m.

What is the fastest connection from Manchester (MHT) to Chicago (ORD)?

via Philadelphia ≈ 2h 50m, via Baltimore ≈ 2h 53m, via Washington ≈ 2h 54m (estimated flying time, excluding layovers).

from 15,000 JAL miles (economy, one way, based on the published award charts).

Manchester-Boston Regional Airport (MHT) to Chicago O'Hare International Airport (ORD)・1,353 km

Nonstop flights available (1 airline). Flight time about 2h 6m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

9 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.