Are there nonstop flights from Mashhad (MHD) to Dushanbe (DYU)?

Yes. Varesh Airlines, Raimon Airways fly this route. Flight time is about 1h 30m.

Mashhad → Dushanbe

Mashhad International Airport (MHD) to Dushanbe International Airport (DYU)・850 km

Nonstop flights available (2 airlines). Flight time about 1h 30m. Nonstop return flights also operate.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.