Are there nonstop flights from McAllen (MFE) to Des Moines (DSM)?

No. The fastest connection is via Dallas-Fort Worth, about 3h 4m of total flying time.

What is the fastest connection from McAllen (MFE) to Des Moines (DSM)?

via Dallas-Fort Worth ≈ 3h 4m, via Austin ≈ 3h 5m, via Houston ≈ 3h 7m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

McAllen Miller International Airport (MFE) to Des Moines International Airport (DSM)・1,759 km

No nonstop flights. The fastest connection is via Dallas-Fort Worth (DFW), about 3h 4m of flying time (layover not included).

With milesJAL 15,000 miles+ (via DFW)ANA 15,000 miles+ (via IAH)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

6 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.