Are there nonstop flights from Mexico City (MEX) to Santiago (STI)?

No. The fastest connection is via Miami, about 4h 51m of total flying time.

What is the fastest connection from Mexico City (MEX) to Santiago (STI)?

via Miami ≈ 4h 51m, via Orlando ≈ 5h 9m, via Panama City ≈ 5h 35m (estimated flying time, excluding layovers).

from 23,000 JAL miles, from 30,000 ANA miles (economy, one way, based on the published award charts).

Mexico City Benito Juárez International Airport (MEX) to Cibao International Airport (STI)・2,982 km

No nonstop flights. The fastest connection is via Miami (MIA), about 4h 51m of flying time (layover not included).

With milesJAL 23,000 miles+ (via MIA)ANA 30,000 miles+ (via PTY)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.