Are there nonstop flights from Mexico City (MEX) to Rome (FCO)?

Yes. Aeroméxico fly this route. Flight time is about 12h 32m.

What is the fastest connection from Mexico City (MEX) to Rome (FCO)?

via Charlotte ≈ 13h 1m, via Atlanta ≈ 13h 2m, via Philadelphia ≈ 13h 2m (estimated flying time, excluding layovers).

from 27,500 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Mexico City Benito Juárez International Airport (MEX) to Rome–Fiumicino Leonardo da Vinci International Airport (FCO)・10,223 km

Nonstop flights available (1 airline). Flight time about 12h 32m. Nonstop return flights also operate.

With milesANA 27,500 miles+ (via EWR)JAL 45,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

34 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.