Are there nonstop flights from Mexico City (MEX) to Johannesburg (JNB)?

No. The fastest connection is via São Paulo, about 18h 30m of total flying time.

What is the fastest connection from Mexico City (MEX) to Johannesburg (JNB)?

via São Paulo ≈ 18h 30m, via Atlanta ≈ 19h 30m, via Newark ≈ 20h 4m (estimated flying time, excluding layovers).

from 35,000 ANA miles, from 50,000 JAL miles (economy, one way, based on the published award charts).

Mexico City Benito Juárez International Airport (MEX) to O.R. Tambo International Airport (JNB)・14,598 km

No nonstop flights. The fastest connection is via São Paulo (GRU), about 18h 30m of flying time (layover not included).

With milesANA 35,000 miles+ (via EWR)JAL 50,000 miles+ (via CDG)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.