Are there nonstop flights from Mexico City (MEX) to São Paulo (GRU)?

Yes. LATAM Brasil, Aeroméxico fly this route. Flight time is about 9h 15m.

What is the fastest connection from Mexico City (MEX) to São Paulo (GRU)?

via Bogota ≈ 9h 49m, via Panama City ≈ 9h 49m, via Lima ≈ 10h 5m (estimated flying time, excluding layovers).

from 30,000 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Mexico City Benito Juárez International Airport (MEX) to São Paulo/Guarulhos–Governor André Franco Montoro International Airport (GRU)・7,433 km

Nonstop flights available (2 airlines). Flight time about 9h 15m. Nonstop return flights also operate.

With milesANA 30,000 miles+ (via BOG)JAL 37,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

20 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.