Are there nonstop flights from Osaka (KIX) to Milan (MXP)?

No. The fastest connection is via Munich, about 12h 19m of total flying time.

What is the fastest connection from Osaka (KIX) to Milan (MXP)?

via Munich ≈ 12h 19m, via Helsinki ≈ 12h 24m, via Seoul ≈ 12h 28m (estimated flying time, excluding layovers).

from 22,500 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Kansai International Airport (KIX) to Milan Malpensa International Airport (MXP)・9,619 km

No nonstop flights. The fastest connection is via Munich (MUC), about 12h 19m of flying time (layover not included).

With milesANA 22,500 miles+ (via HND)JAL 45,000 miles+ (via HEL)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

20 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.