Are there nonstop flights from Osaka (KIX) to Guangzhou (CAN)?

Yes. China Southern Airlines, 9 Air fly this route. Flight time is about 3h 23m.

What is the fastest connection from Osaka (KIX) to Guangzhou (CAN)?

via Xiamen ≈ 3h 56m, via Hangzhou ≈ 3h 56m, via Shanghai ≈ 3h 57m (estimated flying time, excluding layovers).

from 8,500 ANA miles, from 10,000 JAL miles (economy, one way, based on the published award charts).

Kansai International Airport (KIX) to Guangzhou Baiyun International Airport (CAN)・2,455 km

Nonstop flights available (2 airlines). Flight time about 3h 23m. Nonstop return flights also operate.

With milesANA 8,500 miles+ (via HND)JAL 10,000 miles+ (via HND)Economy, one way, estimate. Tap a connection for miles by cabin.

21 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.