Are there nonstop flights from Osaka (KIX) to Karachi (KHI)?

No. The fastest connection is via Beijing, about 8h 47m of total flying time.

What is the fastest connection from Osaka (KIX) to Karachi (KHI)?

via Beijing ≈ 8h 47m, via Bangkok ≈ 10h 17m, via Dubai ≈ 11h 19m (estimated flying time, excluding layovers).

from 19,000 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Kansai International Airport (KIX) to Jinnah International Airport (KHI)・6,543 km

No nonstop flights. The fastest connection is via Beijing (PEK), about 8h 47m of flying time (layover not included).

With milesANA 19,000 miles+ (via PEK)JAL 37,000 miles+ (via DXB)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.