Are there nonstop flights from Houston (HOU) to Columbus (CMH)?

Yes. Southwest Airlines fly this route. Flight time is about 2h 24m.

What is the fastest connection from Houston (HOU) to Columbus (CMH)?

via Nashville ≈ 2h 54m, via St Louis ≈ 3h 4m, via Atlanta ≈ 3h 10m (estimated flying time, excluding layovers).

William P. Hobby Airport (HOU) to John Glenn Columbus International Airport (CMH)・1,610 km

Nonstop flights available (1 airline). Flight time about 2h 24m. Nonstop return flights also operate.

27 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.