Are there nonstop flights from Detroit (DTW) to Santiago (SCL)?

No. The fastest connection is via Miami, about 11h of total flying time.

What is the fastest connection from Detroit (DTW) to Santiago (SCL)?

via Miami ≈ 11h, via Orlando ≈ 11h 1m, via Atlanta ≈ 11h 4m (estimated flying time, excluding layovers).

from 30,000 ANA miles, from 37,000 JAL miles (economy, one way, based on the published award charts).

Detroit Metropolitan Wayne County Airport (DTW) to Comodoro Arturo Merino Benítez International Airport (SCL)・8,504 km

No nonstop flights. The fastest connection is via Miami (MIA), about 11h of flying time (layover not included).

With milesANA 30,000 miles+ (via IAH)JAL 37,000 miles+ (via MIA)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

12 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.