Are there nonstop flights from Des Moines (DSM) to Louisville (SDF)?

No. The fastest connection is via Chicago, about 2h 6m of total flying time.

What is the fastest connection from Des Moines (DSM) to Louisville (SDF)?

via Chicago ≈ 2h 6m, via Chicago ≈ 2h 7m, via Nashville ≈ 2h 17m (estimated flying time, excluding layovers).

from 15,000 JAL miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Louisville Muhammad Ali International Airport (SDF)・772 km

No nonstop flights. The fastest connection is via Chicago (MDW), about 2h 6m of flying time (layover not included).

With milesJAL 15,000 miles+ (via CLT)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.