Are there nonstop flights from Des Moines (DSM) to Newark (EWR)?

Yes. Allegiant Air fly this route. Flight time is about 2h 25m.

What is the fastest connection from Des Moines (DSM) to Newark (EWR)?

via Chicago ≈ 2h 55m, via Detroit ≈ 2h 55m, via Chicago ≈ 2h 56m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Newark Liberty International Airport (EWR)・1,632 km

Nonstop flights available (1 airline). Flight time about 2h 25m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via ORD)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

18 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.