Are there nonstop flights from Des Moines (DSM) to Los Angeles (LAX)?

Yes. American Eagle (airline brand) fly this route. Flight time is about 3h 14m.

What is the fastest connection from Des Moines (DSM) to Los Angeles (LAX)?

via Denver ≈ 3h 45m, via Las Vegas ≈ 3h 45m, via Palm Springs ≈ 3h 46m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Los Angeles International Airport (LAX)・2,324 km

Nonstop flights available (1 airline). Flight time about 3h 14m. Nonstop return flights also operate.

With milesANA 15,000 miles+ (via DEN)JAL 15,000 miles+ (via PHX)Economy, one way, estimate. Tap a connection for miles by cabin.

17 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.