Are there nonstop flights from Des Moines (DSM) to Mexico City (MEX)?

No. The fastest connection is via Austin, about 3h 58m of total flying time.

What is the fastest connection from Des Moines (DSM) to Mexico City (MEX)?

via Austin ≈ 3h 58m, via Dallas-Fort Worth ≈ 3h 58m, via Houston ≈ 3h 58m (estimated flying time, excluding layovers).

from 15,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Mexico City Benito Juárez International Airport (MEX)・2,510 km

No nonstop flights. The fastest connection is via Austin (AUS), about 3h 58m of flying time (layover not included).

With milesJAL 15,000 miles+ (via DFW)ANA 15,000 miles+ (via IAH)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

16 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.