Are there nonstop flights from Des Moines (DSM) to Madrid (MAD)?

No. The fastest connection is via Chicago, about 9h 30m of total flying time.

What is the fastest connection from Des Moines (DSM) to Madrid (MAD)?

via Chicago ≈ 9h 30m, via Boston ≈ 9h 38m, via Newark ≈ 9h 44m (estimated flying time, excluding layovers).

from 37,000 JAL miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Adolfo Suárez Madrid–Barajas Airport (MAD)・7,178 km

No nonstop flights. The fastest connection is via Chicago (ORD), about 9h 30m of flying time (layover not included).

With milesJAL 37,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.