Are there nonstop flights from Des Moines (DSM) to Greenville/Greer/Spartanburg (GSP)?

No. The fastest connection is via Nashville, about 2h 30m of total flying time.

What is the fastest connection from Des Moines (DSM) to Greenville/Greer/Spartanburg (GSP)?

via Nashville ≈ 2h 30m, via Chicago ≈ 2h 40m, via Charlotte ≈ 2h 41m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Greenville-Spartanburg International Airport (GSP)・1,241 km

No nonstop flights. The fastest connection is via Nashville (BNA), about 2h 30m of flying time (layover not included).

With milesJAL 12,000 miles+ (via CLT)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

16 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.