Are there nonstop flights from Des Moines (DSM) to Fresno (FAT)?

No. The fastest connection is via Denver, about 3h 43m of total flying time.

What is the fastest connection from Des Moines (DSM) to Fresno (FAT)?

via Denver ≈ 3h 43m, via Las Vegas ≈ 3h 47m, via Phoenix ≈ 4h 6m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 15,000 JAL miles (economy, one way, based on the published award charts).

Des Moines International Airport (DSM) to Fresno Yosemite International Airport (FAT)・2,299 km

No nonstop flights. The fastest connection is via Denver (DEN), about 3h 43m of flying time (layover not included).

With milesANA 15,000 miles+ (via DEN)JAL 15,000 miles+ (via PHX)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.