Are there nonstop flights from Des Moines (DSM) to Mesa (AZA)?

Yes. Allegiant Air fly this route. Flight time is about 2h 39m.

What is the fastest connection from Des Moines (DSM) to Mesa (AZA)?

via Las Vegas ≈ 3h 49m, via Minneapolis ≈ 3h 50m, via Santa Ana ≈ 4h 23m (estimated flying time, excluding layovers).

Des Moines International Airport (DSM) to Mesa Gateway Airport (AZA)・1,828 km

Nonstop flights available (1 airline). Flight time about 2h 39m. Nonstop return flights also operate.

4 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.