Are there nonstop flights from Cusco (CUZ) to Santa Cruz (VVI)?

No. The fastest connection is via La Paz / El Alto, about 2h 16m of total flying time.

What is the fastest connection from Cusco (CUZ) to Santa Cruz (VVI)?

via La Paz / El Alto ≈ 2h 16m, via Lima ≈ 3h 36m (estimated flying time, excluding layovers).

Alejandro Velasco Astete International Airport (CUZ) to Viru Viru International Airport (VVI)・1,047 km

No nonstop flights. The fastest connection is via La Paz / El Alto (LPB), about 2h 16m of flying time (layover not included).

None.

2 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.