Are there nonstop flights from Buffalo (BUF) to Des Moines (DSM)?

No. The fastest connection is via Detroit, about 2h 27m of total flying time.

What is the fastest connection from Buffalo (BUF) to Des Moines (DSM)?

via Detroit ≈ 2h 27m, via Chicago ≈ 2h 28m, via Chicago ≈ 2h 28m (estimated flying time, excluding layovers).

from 12,000 JAL miles, from 15,000 ANA miles (economy, one way, based on the published award charts).

Buffalo Niagara International Airport (BUF) to Des Moines International Airport (DSM)・1,237 km

No nonstop flights. The fastest connection is via Detroit (DTW), about 2h 27m of flying time (layover not included).

With milesJAL 12,000 miles+ (via ORD)ANA 15,000 miles+ (via ORD)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

13 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.