Are there nonstop flights from Zakynthos (ZTH) to Newcastle upon Tyne (NCL)?

Yes. Jet2.com, TUI Airways fly this route. Flight time is about 3h 31m.

What is the fastest connection from Zakynthos (ZTH) to Newcastle upon Tyne (NCL)?

via Kefallinia Island ≈ 4h 1m, via Amsterdam ≈ 4h 1m, via Düsseldorf ≈ 4h 1m (estimated flying time, excluding layovers).

from 15,000 JAL miles (economy, one way, based on the published award charts).

Zakynthos International Airport "Dionysios Solomos" (ZTH) to Newcastle International Airport (NCL)・2,564 km

Nonstop flights available (2 airlines). Flight time about 3h 31m. Nonstop return flights also operate.

With milesJAL 15,000 miles+ (via LHR)Economy, one way, estimate. Tap a connection for miles by cabin.

25 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.