Are there nonstop flights from Zakynthos (ZTH) to Madrid (MAD)?

No. The fastest connection is via Palermo, about 3h 31m of total flying time.

What is the fastest connection from Zakynthos (ZTH) to Madrid (MAD)?

via Palermo ≈ 3h 31m, via Naples ≈ 3h 33m, via Rome ≈ 3h 35m (estimated flying time, excluding layovers).

from 15,000 ANA miles, from 23,000 JAL miles (economy, one way, based on the published award charts).

Zakynthos International Airport "Dionysios Solomos" (ZTH) to Adolfo Suárez Madrid–Barajas Airport (MAD)・2,125 km

No nonstop flights. The fastest connection is via Palermo (PMO), about 3h 31m of flying time (layover not included).

With milesANA 15,000 miles+ (via ATH)JAL 23,000 miles+ (via LHR)Economy, one way, estimate. Tap a connection for miles by cabin.

None.

46 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.