Are there nonstop flights from Toronto (YYZ) to Karachi (KHI)?

Yes. Pakistan International Airlines fly this route. Flight time is about 14h 14m.

What is the fastest connection from Toronto (YYZ) to Karachi (KHI)?

via Islamabad ≈ 15h 13m, via Istanbul ≈ 15h 17m, via Lahore ≈ 15h 26m (estimated flying time, excluding layovers).

from 40,000 ANA miles, from 45,000 JAL miles (economy, one way, based on the published award charts).

Toronto Pearson International Airport (YYZ) to Jinnah International Airport (KHI)・11,670 km

Nonstop flights available (1 airline). Flight time about 14h 14m. Nonstop return flights also operate.

With milesANA 40,000 miles+ (via IST)JAL 45,000 miles+ (via DXB)Economy, one way, estimate. Tap a connection for miles by cabin.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.