Are there nonstop flights from Toronto (YTZ) to Greenville/Greer/Spartanburg (GSP)?

No. The fastest connection is via Washington, about 2h 22m of total flying time.

What is the fastest connection from Toronto (YTZ) to Greenville/Greer/Spartanburg (GSP)?

via Washington ≈ 2h 22m, via Nashville ≈ 2h 43m, via Newark ≈ 2h 45m (estimated flying time, excluding layovers).

Billy Bishop Toronto City Airport (YTZ) to Greenville-Spartanburg International Airport (GSP)・1,001 km

No nonstop flights. The fastest connection is via Washington (IAD), about 2h 22m of flying time (layover not included).

None.

5 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.