Are there nonstop flights from São Pedro (VXE) to Porto (OPO)?

Yes. easyJet fly this route. Flight time is about 4h 11m.

What is the fastest connection from São Pedro (VXE) to Porto (OPO)?

via Lisbon ≈ 4h 44m, via Espargos ≈ 4h 51m, via Marrakesh ≈ 5h 4m (estimated flying time, excluding layovers).

from 30,000 ANA miles (economy, one way, based on the published award charts).

Cesaria Evora International Airport (VXE) to Francisco de Sá Carneiro Airport (OPO)・3,135 km

Nonstop flights available (1 airline). Flight time about 4h 11m. Nonstop return flights also operate.

With milesANA 30,000 miles+ (via LIS)Economy, one way, estimate. Tap a connection for miles by cabin.

10 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.