Are there nonstop flights from Urgench (UGC) to Madrid (MAD)?

Yes. Uzbekistan Airways fly this route. Flight time is about 6h 41m.

What is the fastest connection from Urgench (UGC) to Madrid (MAD)?

via Bergamo ≈ 7h 12m, via Milan ≈ 7h 13m, via Rome ≈ 7h 14m (estimated flying time, excluding layovers).

from 29,500 ANA miles (economy, one way, based on the published award charts).

Urgench International Airport (UGC) to Adolfo Suárez Madrid–Barajas Airport (MAD)・5,257 km

Nonstop flights available (1 airline). Flight time about 6h 41m. Nonstop return flights also operate.

With milesANA 29,500 miles+ (via IST)Economy, one way, estimate. Tap a connection for miles by cabin.

7 one-stop options, sorted by estimated flying time. Tap one to see the airlines on each leg and booking links.

Times are estimated from distance. Check schedules, frequency and availability with the airline or a booking site.